Pharmaceutical Science & Technology

Next-Gen Therapies for Metabolic and Endocrine Disorders
Beyond Conventional Approaches

Editors: Thakur Gurjeet Singh, PhD
Sanjana Mehta, PhD

Next-Gen Therapies for Metabolic and Endocrine Disorders

Published. Available now.
Pub Date: March 2026
Hardback Price: see ordering info
Hard ISBN: 9781779640581
E-Book ISBN: 978-1-77964-059-8
Pages: 432pp w/index
Binding Type: Hardback / ebook
Notes: 7 color and 37 b/w illustrations


Reviews
“This ground-breaking work represents a significant milestone in our quest to understand and treat metabolic and endocrine disorders more effectively. . . . A comprehensive and forward-thinking resource that delves into the most promising advancements in the field. From gene therapy and stem cell therapy to precision medicine and digital health technologies, this book explores the cutting-edge treatments that are set to redefine how we approach these complex disorders. . . . An invaluable resource, offering up-to-date perspectives on the latest research findings and future directions in the treatment of metabolic and endocrine disorders.”
—From the Foreword by Dr. Gaurav Gupta, Adjunct Research Professor, Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates

“A remarkable book that stands at the forefront of a rapidly evolving field, offering innovative perspectives and cutting-edge solutions to some of the most challenging metabolic and endocrine disorders of our time. . . . Explore[s] groundbreaking therapies that go beyond conventional approaches, addressing the complexities of these disorders with novel strategies and technologies. . . The authors not only discuss the current state of next-gen therapies but also envision future directions and innovations that could further transform the landscape of metabolic and endocrine disorder management. This holistic perspective is invaluable for clinicians, researchers, and students seeking to stay ahead in a field that is continually evolving. An essential reference, guiding healthcare professionals towards more effective, personalized, and innovative treatments.”
—From the Foreword by Dr. Anurag Kuhad, Assistant Professor, University Institute of Pharmaceutical Sciences, Punjab University, India


Addressing the growing need for innovative and effective treatments for metabolic and endocrine disorders, which affect millions of individuals worldwide, this volume explore the cutting-edge developments in the field, offering a comprehensive overview of emerging therapies that promise to revolutionize patient care. From gene therapy and personalized medicine to advancements in pharmacology and biotechnology, this new book encapsulates the future of treatment modalities that promise to revolutionize patient care. Providing a comprehensive review of emerging therapies, supported by robust scientific evidence and clinical trials, the book delves into the mechanisms of action, potential benefits, and practical applications of these next-gen therapies for metabolic and endocrine disorders, offering healthcare professionals a valuable resource to enhance their practice.

Taking a forward-thinking approach, the authors not only discuss the current state of next-gen therapies but also envision future directions and innovations that could further transform the landscape of metabolic and endocrine disorder management. Chapters cover novel therapeutic approaches to metabolic syndromes, such as single-cell transcriptomics, therapeutic approaches to newer classes of drugs and treatments for type 2 diabetes mellitus, the use of artificial intelligence and the internet of things in diagnosis and management of diabetes mellitus, to name a few. The book offers state-of-the-art therapeutic approaches for such health issues as thyroid disorders, type 2 diabetes mellitus, diabetic gastroparesis, high cholesterol, phenylketonuria, cerebrovascular diseases, chronic renal failure, adrenal metabolic disorders, Gaucher disease, Parkinson disease, etc.

An essential reference, guiding healthcare professionals towards more effective, personalized, and innovative treatments, this volume will inspire ongoing research and clinical advancements, ultimately leading to improved outcomes and quality of life for patients worldwide.

CONTENTS:

Foreword by Dr. Gaurav Gupta

Foreword by Dr. Anurag Kuhad

Preface

1. Novel Therapeutic Approaches to Metabolic Syndromes

Selin C. Joy, Unnikrishnan Mk, Prashant Chandra, Govind K. Pradeep, Sivakami Premjith, Muhammed Shafi P. A., Bilha Baby, Anjaly Venugopal, and Keshav Raj Paudel

2. Novel Strategies for Thyroid Disorders: Beyond Hormones
Nitish Bhatia and Benu George

3. Therapeutic Approach of Single-Cell Transcriptomics: Emergence in Metabolic and Endocrine Disorders
Neha Kukreti, Shilpa Rana, Thakur Gurjeet Singh, Diksha Sharma, Gabriele De Rubis, and Sanjana Mehta

4. Therapeutic Approaches to Newer Classes of Drugs and Treatments for Type 2 Diabetes Mellitus
Abhik Paul, Sai Satyaprakash Mishra, Sourin Nahar, Avik Maji, Tapas Kumar Bhowmick, Tapan Kumar Maity, and Venkata Sita Rama Raju Allam

5. Recent Applications of Artificial Intelligence and the Internet of Things in Diagnosis and Management of Diabetes Mellitus
Ling Dai, Mengli Kang, Lili Liu, and Haipeng Liu

6. Investigation of Anti-Hyperlipidemic Activity of Trapa bispinosa Fruit Peel Extract on HFD-Induced Mice Model
Kumar Anand, Sayak Khawas, Mahendra Pratap Chopra, Neelima Sharma, and Brian G. Oliver

7. Metabolic Crisis: Phenylketonuria
Deepti M. Sati, Neha Chauhan, Deepika Raina, Lovleen Kaur, Sanjana Mehta, and Thakur Gurjeet Singh

8. Diabetic Gastroparesis: Current Trends in Management
Nidhi Garg, Henaroop Tiwana, Sarita Jangra, Shaima K. A., Poonam Maurya, Sanjana Mehta, and Thakur Gurjeet Singh

9. Management of Complications Arising from Cerebrovascular Events with Pharmaceutical Interventions
Naina Dubey, Sampat Singh Tanwar, Neelima Goswami, Ramandeep Singh, Seema Sharma, and Sanjeev Sharma

10. Relevant Therapeutic Approaches to Chronic Renal Failure
Rupinder Kaur, Rajwinder Kaur, Amrit Kaur, Iresha, Ujjwal Kaushik, Ravinder Singh, Balakumar Chandrasekaran, Thakur Gurjeet Singh, and Sanjana Mehta

11. Unraveling the Metabolic Complexities of Gaucher Disease and Its Correlation with Parkinsons Disease
Prachi Mall, Deepika Raina, Sona Kakkar, Pranjal Garg, Karabi Kalita, and Nitin Chitranshi

12. A Brief Review on the Role of Various Molecular Targets and Pharmacological Strategies for Diabetic Wound Healing
Amrita Das, Nibir Ghosh, Sangita Palai, Gourab Dey, Laiba Parveen, and Terezinha De Jesus Andreoli Pinto

13. Epigenetic Modifications and Metabolic Health
Seema Sharma, Sneha Kumari, Naina Dubey, Sampat Singh Tanwar, and Amit Khurana

14. The Major Pathways and Treatment Approaches Involved in Adrenal Metabolic Disorders
Himanshu Sharma, Praveen Halagali, Devika Nayak, Vamshi Krishna Tippavajhala, Rashmi Pathak, and Srinivas Nammi

15. Exploring Nutritional Strategies for Polycystic Ovary Syndrome Management
Deepika Raina, Prachi Mall, Stuti Goyal, Karabi Kalita, Loveleen Kaur, Flavia C. Zacconi, Thakur Gurjeet Singh, and Sanjana Mehta

16. Prenatal Stress and Risk Factors for Metabolic Disease: The Mediating Role of DNA Methylation
Sampat Singh Tanwar, Seema Sharma, Manali Parkhi, Ramandeep Singh, Naina Dubey, and Sheema Khan

17. Pharmacotherapeutic Potential and Clinical Efficacy of Microbiota in Metabolic Disorders
Satnam Singh, Amandeep Kaur, Thakur Gurjeet Singh, Sanjana Mehta, Ashi Mannan, Divya Kanwar, Bhavesh Dharmani, and Sofia Kokkinis

Index


About the Authors / Editors:
Editors: Thakur Gurjeet Singh, PhD
Dean, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Thakur Gurjeet Singh, PhD, brings to the forefront a wealth of expertise and leadership cultivated through his role as Dean at Chitkara College of Pharmacy, Chitkara University, Punjab. Dr. Singh is globally recognized researcher consecutively for last three years as one of the top 2% of scientists, an honor bestowed by Stanford University. Spanning over 17 years, his academic and industrial experience is distinguished by more than 470 published papers, accruing an impressive 7923 citations, reflecting his significant scholarly impact, characterized by an H-Index surpassing 47 and an i10 Index of 164. Notably, his contributions are underscored by an impact factor of 1190.5 and an RG Score of 1598. With a doctoral specialization in pharmacology and a prolific career focused on neuropharmacology, substance dependence, pharmacological preconditioning, and drug discovery, Dr. Singh has mentored more than 22 PhD scholars and over 108 postgraduate research candidates, contributing significantly to translational science in neurodegenerative and metabolic disorders. His expertise spans both preclinical and clinical research, with deep insights into animal modeling, behavioral pharmacology, and experimental therapeutics. Under his visionary leadership, the Chitkara College of Pharmacy became the first institute in Punjab to establish the Indian Pharmaceutical Association–Students’ Forum’s (IPA-SF) Punjab State Chapter, fostering professional engagement and national-level visibility for student pharmacists. He also serve as Faculty Advisor at ISPOR–The Professional Society for Health Economics and Outcomes Research Student Chapter at the Chitkara College of Pharmacy, empowering students to explore health economics, outcomes research, and value-based healthcare practices. In his role as the National Vice President of the Society of Clinical Research and Medical Professionals (SCRMP–International), he contributes to advancing global standards in clinical research, education, and professional excellence. An editorial board member and editor of the Journal of Pharmaceutical Technology, Research and Management, Dr. Singh is a recognized contributor to scholarly publishing. His academic footprint includes numerous book chapters published by global leaders such as Elsevier, Springer Nature, Taylor & Francis, and Apple Academic Press, in areas ranging from nanotechnology and diabetes management to pharmacoeconomics and clinical therapeutics. He also serves as Director, Quality Management System at the Herbal and Ayush Product Testing and Standardization Lab (HAPTSL) at Chitkara University’s College of Pharmacy, where he leads efforts to ensure global regulatory compliance through advanced instrumentation and a multidisciplinary team committed to excellence in Ayurvedic product standardization. He has received multiple prestigious awards, including the outstanding researcher award, teacher’s excellence awards, and accolades for innovation, patent filings, and research consultancy. Dr. Singh’s enduring commitment to academic excellence, scientific inquiry, and institutional growth continues to elevate Chitkara College of Pharmacy as a hub of innovation, regulatory alignment, and interdisciplinary research in India’s pharmaceutical landscape. Dr. Singh has an MPharm (Pharmaceutical Sciences—Pharmacology), PDCR (Clinical Research & PCPV (Pharmacovigilance), and PhD (Pharmaceutical Sciences), Punjab, India.

Sanjana Mehta, PhD
Assistant Professor, HOD (PharmD), Chitkara College of Pharmacy, Chitkara University, Punjab, India

Sanjana Mehta, PhD, is a dedicated academician, researcher, and innovation mentor with PharmD and PhD degrees in Pharmaceutical Sciences. Currently serving as Assistant Professor and HOD (PharmD) at the Chitkara College of Pharmacy, Chitkara University (Punjab), she brings over five years of experience in academic leadership, clinical pharmacology, and translational research. She actively coordinates the Institutional Innovation Cell (IIC) where she fosters a vibrant ecosystem for student-led innovation, start-up incubation, and interdisciplinary research. In her roles as Education Officer of the ISPOR–The Professional Society for Health Economics and Outcomes Research Student Chapter, Faculty Coordinator for Indian Pharmaceutical Association–Students’ Forum’s (IPA-SF) Punjab State Chapter, and Faculty Adviser at Society of Clinical Research and Medical Professionals (SCRMP) Student Forum Punjab State Chapter (Pharmacy Wing), Dr. Mehta empowers students to engage with global trends in pharmacoeconomics, public health policy, and community pharmacy practice. Beyond research, she is a trained professional in vaccine administration and basic life support (BLS) under the prestigious Indian Pharmaceutical Association and the International Pharmaceutical Federation (IPA-FIP) collaborative “Train the Trainer” program, equipped with hands-on expertise in vaccine delivery, CPR, AED use, and ethical emergency response protocols. This training further enhances her role in healthcare education and community outreach. She continues to mentor PharmD, MPharm, and PhD scholars in innovative, patient-centered research. Her research focus lies in advanced pharmacotherapeutics, metabolic disorders, and patient-centric innovations, with several patents and funded projects to her credit. She also has a registered Copyright (L-110308/2022) to her credit, the DN-22 QoL Questionnaire (Diabetic Neuropathy Quality of Life Questionnaire). Recognized with awards including the Best PhD Award, Dr. Mehta is known for her academic rigor, mentoring excellence, and commitment to public health advancement.




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