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Now Available in Paperback CONTENTS: About the Authors / Editors: Editor: Tatiana G. Volova, DSc Professor and Head, Department of Biotechnology, Siberian Federal University, Krasnoyarsk, Russia Tatiana G. Volova, DSc, is Professor and Head, Department of Biotechnology at Siberian Federal University, Krasnoyarsk, Russia. She is the creator and head of the Laboratory of Chemoautotrophic Biosynthesis at the Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences. Professor Volova is conducting research in the field of physico-chemical biology and biotechnology and is a well-known expert in the field of microbial physiology and biotechnology. Dr. Volova has created and developed a new and original branch in chemoautotrophic biosynthesis, in which the two main directions of the XXI century technologies are conjugate, hydrogen energy and biotechnology. The obtained fundamental results provided significant outputs and were developed by the unique biotechnical producing systems, based on hydrogen biosynthesis for single-cell protein, amino acids, and enzymes. Under the guidance of Professor Volova, the pilot production facility of single cell protein, utilizing hydrogen, had been created and put into operation. The possibility of involvement of man-made sources of hydrogen into biotechnological processes as a substrate, including synthesis gas from brown coals and vegetable wastes, was demonstrated in her research. She had initiated and deployed in Russia the comprehensive research on microbial degradable bioplastics; the results of this research cover various aspects of biosynthesis, metabolism, physiological role, structure, and properties of these biopolymers and polyhydroxyalkanoates (PHAs), and have made a scientific basis for their biomedical applications and allowed them to be used for biomedical research. Professor Volova is the author of more than 300 scientific works, including 13 monographs, 16 inventions, and a series of textbooks for universities. Ekaterina I. Shishatskaya, DSc Professor and Head, Department of Medical Biology, Siberian Federal University, Krasnoyarsk, Russia Ekaterina I. Shishatskaya, DSc, is Professor and Head, of the Department of Medical Biology at Siberian Federal University, Krasnoyarsk, Russia, and a leading researcher at the Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, in Krasnoyarsk, where she supervises the direction of biomedical research of new materials. Dr. Shishatskaya’s work includes an investigation of interaction mechanisms between biomaterials and biological objects and development of high-tech biomedical devices. This actual science direction is oriented to the development of new reconstructive biomedical technologies, which includes cell biology and tissue engineering and biodegradable polymers of carbon acids–polyhydroxyalkanoates (PHAs), a new class of materials for medicine. Under her leadership, technologies for encapsulating of biologically active and medical substances in the polymer matrix have been developed. The release kinetics of substances in depending on the geometry of the polymer matrix and the loading of substances was investigated. Dr. Shishatskaya is Russian leader in comprehensive medical and biological studies of this class of polymers. Her professional activity is focused on the implementation of the obtained results in practice, and she maintains communication with clinical centers and top specialists in regenerative medicine. Dr. Shishatskaya is author of about 150 research works, including six monographs and eight patents. She is the winner of the President of Russian Federation for youth in the field of science and innovations and holds a State Prize of the Krasnoyarsk Region in the area of higher education and science. She is also a laureate of L’Oréal-UNESCO for young women in science. Natalia O. Zhila, PhD Assistant Professor, Department of Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation; Senior Researcher, Institute of Biophysics, Siberian Branch of Russian Academy of Sciences Natalia O. Zhila, PhD, is an Assistant Professor in the Department of Biotechnology at Siberian Federal University, Krasnoyarsk, Russian Federation, and also a Senior Researcher at the Institute of Biophysics, Siberian Branch of Russian Academy of Sciences. She investigates biosynthesis of polyhydroxyalkanoates of different structure and their properties. She has conducted studies of biosynthesis of co-, ter and quarterpolymers containing various monomers: 3-hydroxyvalerate, 3-hydroxyhexanoate, 4-hydroxybutyrate, and diethylene glycol using chemolithoautotrophic bacteria. In addition, her work also includes various aspects of physiology and biochemistry of microorganisms consisting in the study of the features of growth of bacteria, polymer synthesis and fatty acid composition of lipid of the cytoplasmic membrane, and cell walls in different conditions of cultivation. She also studies polyhydroxyalkanoates metabolism, including number and size of polymer granules in cells, the molecular weight of polymer, and the activity of enzymes of polymer biosynthesis and intracellular degradation. Dr. Zhila is an author of about 70 research works, including two monographs. Svetlana V. Prudnikova, DSc Professor, Biotechnology Department, Siberian Federal University, Krasnoyarsk, Russia Svetlana V. Prudnikova, DSc, is a Professor in the Biotechnology Department at Siberian Federal University, Krasnoyarsk, Russia. She works in area of microbiology, focusing on ecology and physiology of microorganisms, microbial biotechnology, and biodegradable microbial polymers. She has conducted studies of microbiological degradation of polyhydroxyalkanoates in different climatic zones and has described microbial communities of PHA-degrading microorganisms that dominate in tropical soil and seawater and in Siberian natural and agrogenically transformed soils. Besides PHA, Dr. Prudnikova is also studying the biosynthesis of bacterial cellulose, another microbial degradable and biocompatible polymer. The area of her research interests includes processes of microbial biodegradation of organic matter in soil ecosystems, soil microbiology, and bioremediation. Dr. Prudnikova is an author of about 50 scientific and methodical works, including 24 papers in peer-reviewed journals, two monographs, two patents, and five textbooks for students of biological specialties of universities. Anatoly N. Boyandin, PhD Associate Professor, Department of Biotechnology, Siberian Federal University; Researcher, Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, Russia Anatoly N. Boyandin, PhD, is an Associate Professor of Department of Biotechnology at Siberian Federal University, and also a researcher at the Institute of Biophysics, Siberian Branch of Russian Academy of Sciences in Krasnoyarsk, Russia. His work includes different aspects of biosynthesis, modification, biodegradation, and application of bacterial polyhydroxyalkanoates (PHAs). Dr. Boyandin has investigated mechanisms of polyhydroxyalkanoate biosynthesis by Vibrio and Photobacterium spp. He has studied biodegradability of PHAs in water and soil environments of different climate zones. New technologies of obtaining PHA composites have been developed by Dr. Boyandin, which have provided improvement of mechanical properties of goods while preserving high biocompatibility. In addition, he has worked out new approaches to biopolyester surface modification based on chemical and physical treatment and aimed to increase of polymer hydrophilicity and biocompatibility. He has developed a new technology of casting solution processing biopolymeric materials into tube goods for further use of them as endoprostheses in urology. He has developed new agricultural formulations based on a structure “composite core—biopolymeric coating.†|
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