Pharmaceutical Science & Technology

Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease, 2-volume set:
Volume 1: Targeting Key Pathological Pathways / Volume 2: Strategies to Unlock the Brain’s Fortress

Editors: Varinder Singh, PhD
Amit Kumar, PhD
Parul Sood, PhD

Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease, 2-volume set:

Now on Press
Pub Date: Forthcoming April 2025
Hardback Price: $400 US | £315 UK
Hard ISBN: 9781774918449
E-Book ISBN: see individual volumes
Pages: 6pp w/index
Binding Type: Hardback / ebook
Notes: 66 b/w illustrations

The number of people living with dementia is expected to rise from 55 million in 2019 to 139 million in 2050, according to a report by WHO. Treatments and potential cures for Alzheimer’s have been researched for a long time now. Conventional drugs, while providing symptomatic relief, have often fallen short of halting the relentless progression of this neurodegenerative disorder. This new two-volume set, Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease, 2-volume set, represents a collective effort to delve into the potential of nature’s pharmacopeia in our battle against Alzheimer’s disease. The editors posit that essential insights into the intricacies of the disease are the foundation for subsequent discussions on potential therapeutic interventions.

Volume 1: Targeting Key Pathological Pathways first lays the foundation by unveiling the underlying pathological, biochemical, molecular, and genetic aspects of Alzheimer’s disease. These chapters provide essential insights into the intricacies of the disease and serve as a springboard for the subsequent discussions on potential therapeutic interventions. Chapters cover pathophysiology and diagnosis, the connection of gut microbiome and Alzheimer’s disease, drug-induced Alzheimer’s disease, and more. The volume then goes on to shine a spotlight on the vast potential of nutraceuticals in managing Alzheimer’s disease. It explores a plethora of medicinal plants and their secondary metabolites that show promise in treating this devastating condition. From preclinical findings to clinical studies, the chapters present a wealth of knowledge on memory improvement effects and the mechanisms underlying the actions of these neuro-nutraceuticals. Covered are the role of diet, micronutrients, and macronutrients in managing Alzheimer’s disease; Medhya Rasayana (medicinal plants described in the Indian system of medicine that are said to improve memory and intellect); nootropics (also known as drug cognitive enhancers that help to improve memory, increase mental alertness and concentration as well as boost energy levels and wakefulness); and other ethnopharmacological approaches for dementia.

Volume 2: Strategies to Unlock the Brain’s Fortress offers a comprehensive exploration into the cutting-edge strategies for the pursuit of effective Alzheimer’s management. The first section of this volume is dedicated to a holistic exploration of nutraceuticals and their pivotal role in managing Alzheimer’s disease, serving as a guide to the diverse array of neuro-nutraceuticals and providing insights into their mechanisms, efficacy, and potential integration into holistic Alzheimer’s management strategies. The chapter authors look at natural antioxidant therapeutics, natural steroidal phytopharmaceuticals and Terpenes (aromatic compounds found in many plants), anti-apoptotic natural products, polysaccharides, neuro-protective role of vitamin D, non-flavonoidal agents for the effective treatment of Alzheimer’s. Recent developments and advancements in the delivery of nutraceuticals are explored as well, looking at nanotechnology and advanced drug delivery systems for therapeutic interventions in Alzheimer’s disease.

Together, these volumes not only reflect the current state of knowledge but also pave the way for future exploration in the field. Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease will enlighten readers, whether seasoned researchers, practitioners, or advanced students, with a wealth of scientific knowledge gained through the cutting-edge research and in-depth exploration of the therapeutic potential of nature’s offerings and shall contribute to the ongoing efforts in managing dementia and cognitive disorders.

Click here for Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease, 2-volume set:

Click here for Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease, Volume 1: Targeting Key Pathological Pathways

Click here for Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer’s Disease, Volume 2: Strategies to Unlock the Brain’s Fortress

CONTENTS:
VOLUME 1: TARGETING KEY PATHOLOGICAL PATHWAYS

Preface

PART I: MOLECULAR AND GENETIC PATHWAYS IN ALZHEIMER’S DISEASE
1. Pathophysiology and Diagnosis of Alzheimer’s Disease: Past and Recent Developments

Nirmal Singh, Kuldeep Kumar, Simrat Kaur, Ayush Kandpal, Harlokesh Narayan Yadav, Dhandeep Singh, Dimple Sethi Chopra, Amteshwar Singh Jaggi, Amit Kumar, and Vasudevan Mani

2. Tangled Connection of Gut Microbiome and Alzheimer’s Disease
Rohini Pujari, Satish Shilpi, Kamal Dua, Shreya Sharma, and Shvetank Bhatt

3. Epigenetic Modifications in Alzheimer’s Disease
Rahul Kumar, Prachi Parvatikar, Indrani Maji, Shashi Bala Singh, And Pankaj Kumar Singh

4. Drug-Induced Alzheimer’s Disease
Monika Kaushik, K. Anitha, and S. Vijayaraj

5. The Road to Drug Discovery Targeting Abnormal Proteins: Taking a Glance at Alzheimer’s Treatments Through Rose-Colored Glasses
Shiveena Bhatia, Varinder Singh, Mohit Kumar, Manjinder Singh, Amit Kumar, Kavita Munjal, Hasandeep Singh, and Tanveer Singh

6. Preclinical Testing Methods for Evaluation of Potential Anti-Alzheimer’s Drugs
Mintu Mathew, Vaishnavi R. Unnithan, Rajan Swami, Jaya Thomas, and Manish Kumar Jeengar

PART II: NUTRACEUTICALS FOR THE MANAGEMENT OF ALZHEIMER’S DISEASE
7. Medhya Rasayanas for the Management of Alzheimer’s Disease

Nikita Nain, Kavita Munjal, Vinod Kumar Gauttam, Sumeet Gupta, Varinder Singh, and Shreya Kaul

8. Management of Alzheimer’s Disease in the Light of Ayurveda
Sunayna Choudhary, Kavita Munjal, and Vinod Kumar Gauttam

9. Nootropics: Traditional Medicinal Prospective
Preeti Maan, Nisha Gupta, and Shilpi Chauhan

10. Ethnopharmacological Approaches for Dementia
Kamica Yadav, Arun Mittal, Parveen Kumar Goyal, Satish Sardana, and Suman Khurana

11. Role of Diet, Micronutrients, and Macronutrients in Managing Alzheimer’s Disease
Anuradha Mishra, Sunayna Choudhary, Vinod Kumar Gauttam, and Kavita Munjal

Index

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VOLUME 2: STRATEGIES TO UNLOCK THE BRAIN’S FORTRESS

Preface

PART I: NUTRACEUTICALS: HOLISTIC APPROACHES TO ALZHEIMER’S MANAGEMENT

1. Emergent Natural Antioxidant Therapeutics to Cope with Oxidative Stress in Alzheimer’s Disease
Anandita Gulati, Rajwinder Kaur, Damanpreet Kaur Lang, Nidhi Rani, and Balakumar Chandrasekaran

2. Exploring Beta Secretase Inhibitors as the Evergreen Drug Target for Alzheimer’s Disease: Calling Herbal Therapies to the Rescue
Shiveena Bhatia, Manjinder Singh, Amit Kumar, Varinder Singh, Kavita Munjal, Mohit Kumar, Tanveer Singh, and Hasandeep Singh

3. Role of Natural Steroidal Phytopharmaceuticals in the Management of Alzheimer’s Disease
Pallavi Bassi, Sushma Devi, Shivani Rana, Ankita Thakur, and Jangjeet Karan Singh

4. Potential Role of Terpenes in the Management of Alzheimer’s Disease
Diksha Sharma, Amit Kumar, Ayushi Negi, Manjinder Singh, Varinder Singh, and Mohit Kumar

5. Anti-Apoptotic Natural Products for the Management of Alzheimer’s Disease
Hasandeep Singh, Gurpreet Singh, Loveleen Kaur, Sarabjit Kaur, Gurkiran Kaur, Gurbaj Singh, Balbir Singh, and Varinder Singh

6. Potential Natural Polysaccharides for the Management of Alzheimer’s Disease
Sonia Dhiman, Devanshi Mehta, and Thakur Gurjeet Singh

7. Neuro-Protective Role of Vitamin D in Alzheimer’s Disease
Sarita Jangra, Bhupinder Bhyan, Preetpal Singh, Lakshita Taneja, Shweta Maan, Tanya Sood, Shaima Ka, Nishant Johri, and Ravinder Singh

8. Role of Non-Flavonoidal Agents in Alzheimer’s Disease
Shreya Sood, Neeraj Mittal, Gagandeep Kaur, Sima Singh, and Sushma Devi

PART II: RECENT DEVELOPMENTS AND ADVANCEMENTS IN THE DELIVERY OF NUTRACEUTICALS ACROSS BLOOD-BRAIN-BARRIER
9. Drug Delivery Strategies for Drug Targeting for Alzheimer’s Disease

Divyasree Kandipati, Jyoti Dange, Teenu Sharma, Manish Kumar Jeengar, and Rajan Swami

10. Nanocargos for Efficient Delivery of Nutraceuticals Across Blood-Brain Barrier
Yukta Guggal, Trupti Dandekar, Rajan Swami, and Teenu Sharma

11. Recent Advancement in Strategies for Delivery of Neuronutraceuticals to the Brain
Suman Khurana, Arun Mittal, Parveen Kumar Goyal, Shrestha Sharma, Satish Sardana, Kamica Yadav, and Parul Sood

Index


About the Authors / Editors:
Editors: Varinder Singh, PhD
Assistant Professor, Department of Pharmaceutical Sciences & Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India

Varinder Singh, PhD, is working as Assistant Professor in the Department of Pharmaceutical Sciences and Technology at Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India. His research interests primarily lie in the discovery and development of natural products for therapeutic use. He is well-versed in the fields of natural product chemistry (isolation and characterization of bioactive natural compounds), drug discovery, and pharmacology. He has a strong record of publications in high-impact peer-reviewed journals (39 peer-reviewed publications), with many of his papers cited extensively in the field of natural products. He has one patent granted. He has been awarded with numerous travel grants from government and non-government organizations, including the Alzheimer’s Association International, the Indian Department of Science and Technology, Indian Council of Medical Research, and International Brain Research Organization. He earned his PhD (Pharmaceutical Sciences) at Punjabi University, Patiala, Punjab, India.

Amit Kumar, PhD
Associate Professor, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Amit Kumar, PhD, is working as Associate Professor at Chitkara College of Pharmacy, Chitkara University, Punjab, India. He has 12 years of teaching and research experience and has published more than 20 research articles in international journals. He has to date 371 citations and an h-index of 11. He has filed three patents. His area of research includes neuroprotective drug development and elucidating pathological features of diseases. He has received various awards and grants from the International Brain Research Organization, the Indian Department of Science and Technology (DST)-Science and Engineering Research Board, and the Indian Council of Medical Research. He is a certified trainer of Scientific Medical Writing approved from the Life Sciences Sector Skill Development Council and DST (Govt. of India). He received his graduate, postgraduate, and PhD degrees in Pharmaceutical Sciences from Punjabi University Patiala, Punjab, India.

Parul Sood, PhD
Associate Professor, Chitkara School of Pharmacy, Chitkara University, Himachal Pradesh, India

Parul Sood, PhD, is working as an Associate Professor at Chitkara School of Pharmacy, Chitkara University, Himachal Pradesh, India. She has more than 14 years of professional experience in teaching and research. Her area of specialization and research is exploring herbal plants for the treatment of various neurological disorders including, Alzheimer’s disease, as well as pharmacognostical and phytochemical evaluation, and standardization of herbal drugs and herbal drug formulation development. She is a gold medalist in MPharm and GATE as well as GPAT qualified. She has a total of 12 publications in reputed journals and has presented a total of 15 oral/poster presentations at national and international conferences and was awarded third position at two national conferences. She completed her PhD at the Department of Pharmaceutical Sciences, Punjabi University Patiala, Punjab, India.




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