Pharmaceutical Science & Technology

Nanomedicine for Neurodegenerative Disorders
Selective Treatment Strategies

Editors: Rishabha Malviya, PhD
Kamla Pathak, PhD
Swati Verma, MPharm

Nanomedicine for Neurodegenerative Disorders

In Production
Pub Date: Forthcoming February 2024
Hardback Price: $240 US | £180 UK
Hard ISBN: 9781774916124
Pages: Est. 577pp w/index
Binding Type: Hardback / ebook
Notes: 53 b/w illustrations


Reviews
“This book will, in my belief, be helpful for healthcare professionals in treating neurodegenerative disorders. It will give readers profound insights into the recent uses of several cutting-edge nanocarriers that contain active pharmaceutical ingredients for the effective treatment of illnesses connected to neurons.”
—From the Foreword by Dr. Brahmeshwar Mishra, Professor (HAG Scale) and Former Head, Department of Pharmaceutical Engineering and Technology, IIT (BHU), Varanasi, Uttar Pradesh, India


With the population getting older and with a corresponding increase in neurodegenerative diseases (NDs) worldwide, developing drug delivery systems that can overcome conventional barriers in treating these diseases is the need of the hour. Drug delivery by nanotechnology has great promise for detecting and treating a wide range of neurodegenerative conditions. This new book provides an informative overview of the cutting-edge applications of various nanocarriers that encapsulate active compounds to effectively treat NDs.

Providing a comprehensive review of neurological disorders, clinical strategies for the management of neuro disorders, and the challenges in their treatment, the book first reviews the types, diagnosis, and treatment strategies, including biomarkers in detection, diagnosis, and prognosis of neurodegenerative disorders. It then provides an overview of the blood-brain barrier (BBB) transport mechanisms. It discusses specific techniques such as the delivery of RNA/DNA to the brain using nanoscience, nanodiamonds as emerging nanotherapeutics for brain-targeted drug delivery, the use of herbal nano-formulations, and more.

Clinical researchers and other scientists working to reduce the obstacles to delivering drugs and genes in a more efficient and targeted manner for the treatment of neurodegenerative diseases will find Nanomedical Drug Delivery for Neurodegenerative Diseases to be an invaluable resource.

CONTENTS:
Foreword by Brahmeshwar Mishra

Preface

1. Neurodegenerative Disorders: Concepts, Types, and Treatment Strategies
Chandana Majee, Rupa Mazumder, and Bhawani Pantela

2. Overview of the Blood-Brain Barrier (BBB) Transport Mechanisms
Shilpa Verma, Mahesh Gaikwad, Gajanan Paul, and A. K. Yadav

3. Nanodiamonds as Emerging Nanotherapeutics for Brain-Targeted Drug Delivery in the Management and Diagnosis of Neurodegenerative Disorders
Bhagawati Saxena, Fagun Pathak, Bhavna Bohra, and Viral Shah

4. The Real Issue in Targeting Neurodegenerative Disease
Smriti Ojha, Anubhav Ananad, Hina Chadha, and Sudhanshu Mishra

5. Strategies to Cross the Blood-Brain Barrier
Shraddha Dwivedi

6. Nanotechnology-Based Drug Delivery Systems for the Treatment of Neurodegenerative Disorders
Himanshu Paliwal, Bhupendra G. Prajapati, and Teerapol Srichana

7. Nano Approaches Towards CNS Drug Delivery
Ashwani Sharma, Anjali Sharma, Girish Kumar, Tarun Virmani, and Kamla Pathak

8. Current Trends in Drug-Nano Formulations Directed to the Brain
Dignesh Khunt, Brijesh Shah, Smit Nayi, Akshay Parihar, and Bhupendra Prajapati

9. Selection of an Appropriate Technique for Nano-Carrier Preparation: A Multi-Criteria Decision-Making Methodology
Pankaj Sharma

10. Delivery of RNA/DNA to the Brain Using Nanoscience
Akanksha Sharma, Ashish Verma, Aditi Singh, and Rishabha Malviya

11. Application of Medicinal Plants and Their Phytoconstituents Used in the Management of Neurodegenerative Diseases
Padmini Shukla and Prabodh Shukla

12. Molecular Mechanisms Underpinning Neuroprotection of Nutritional Polyphenols
Johnson O. Oladele, Isaac O. Babatunde, and Oluwaseun T. Oladele

13. Implication of Herbal Nano-Formulations in the Treatment of Neurological Disorders
Sunny R. Shah, Vijay R. Chidrawar, Prashant L. Pingale, Sudarshan Singh, Bhupendra Prajapati, and Devang Sheth

14. Medical Laboratory Diagnosis of Neurodegenerative Diseases Towards Adequate Treatment in Nanomedicine
Uchejeso Mark Obeta, Amaechi Eze Odono, Nkereuwem Sunday Etukudoh, and Obiora Reginald Ejinaka

15. Role of Biomarkers in Detection, Diagnosis, and Prognosis of Neurodegenerative Disorders
Ruchi Singh, Ankita Moharana, Srishti Tiwari, Soubhik Bhattacharyya, Garima Tripathi, and Dhanalekshmi Unnikrishnan Meenakshi

16. Use of Nano-Formulations in the Treatment of Neurodegenerative Disorders
Ujjwal Gupta, Suryawanshi Ajay, Farhan Mazahir, and A. K. Yadav

17. Nanostructured Drug Carriers for Nose-to-Brain Drug Delivery in the Treatment of Neurological Disorders
Noopur Srivastava, Pawan Upadhyay, Alka Srivastava, Shibu Das, and Sudhanshu Mishra

Index


About the Authors / Editors:
Editors: Rishabha Malviya, PhD
Associate Professor, Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

Rishabha Malviya, PhD, has 11 years of research experience and is presently working as Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 150 research and review papers for national and international journals of repute. He holds over 50 patents and has published many papers in reputed national and international journals, for which he received an outstanding reviewer award from Elsevier. He has edited 13 books (Wiley, Springer Nature, CRC Press/Taylor and Francis, Apple Academic Press, River Publisher, Lambert, and OMICS Publishing Group) and authored 15 book chapters. His name has been included in the World‘s Top 2% Scientists list by Elsevier BV and Stanford University. He is reviewer, editor, and editorial board member of more than 50 national and international journals. He was an invited author for the magazine Atlas of Science as well as a pharma magazine dealing with B2B industry, Ingredient South Asia. He completed a BPharm from Uttar Pradesh Technical University and MPharm (Pharmaceutics) from Gautam Buddha Technical University, Lucknow Uttar Pradesh. His PhD (Pharmacy) work was in novel formulation development techniques.

Kamla Pathak, PhD
Dean and Professor, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, India

Kamla Pathak, PhD, is Dean and Professor, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, India. With teaching and research experience of more than 30 years, she is actively engaged in research on oral controlled, modulated, and targeted and topical drug delivery systems, and has received many awards for her work. She has over 270 publications in journals of international and national repute. She also holds three patents and has authored four books and more than 20 book chapters. She has also written many abstracts in various scientific forums and has been a reviewer for national and international journals in pharmaceutics. Professor Pathak has served as a member of the editorial advisory board of AAPS Pharm Sci Tech and is also a member of various professional bodies. She has guided more than 120 PhD and postgraduate students. She is also associated with the Indian pharmaceutical industry in the capacity of a scientific consultant. She is credited as reviewer of several scientific projects including Knowledge Foundation, Sweden, and Israel Science Foundation. She has participated at national and international seminars and conferences as organizer, invited speaker, and chairperson of scientific sessions. She has been listed in the top 2% Indian scientists in the subsection Pharmacology and Pharmacy, in the World‘s Top 2% Scientists list released by Stanford University in 2020 and 2021. She graduated (Pharmaceutics) from the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, earning her doctorate in Pharmacy in 1991 from the same institute.

Swati Verma, MPharm
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

Swati Verma, MPharm, is currently working in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. Her areas of interest are in computer-aided drug design, analytical chemistry, targeted drug delivery, and nanoformulation. She has authored four book chapters, edited two books, and many review papers published in international journals. She completed a BPharm at Dr. A.P.J. Abdul Kalam Technical University and MPharm (Pharmaceutical Chemistry) at Banasthali Vidyapith, Rajasthan, India. Her PhD work is in neurodisorders.




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