Pharmaceutical Science & Technology

Cellular and Molecular Mechanisms in Alzheimer”s Disease Therapeutics, Volume 1
Volume 1: Cellular Mechanisms

Editors: Prashant Tiwari, PhD
Sunil Kumar Kadiri, PhD
Kunjbihari Sulakhiya, PhD

Cellular and Molecular Mechanisms in Alzheimer”s Disease Therapeutics, Volume 1

In production
Pub Date: Forthcoming December 2025
Hardback Price: $200 US | £150 UK
Hard ISBN: 9781779641786
Pages: Est. 377pp w/index
Binding Type: Hardback / ebook
Notes: 28 b/w illustrations

Alzheimer’s disease (AD) stands as a profound and growing global health concern, characterized by progressive neurodegeneration and cognitive decline. As research into the underlying causes of AD advances, it becomes clear that a deeper understanding of its molecular mechanisms is crucial for the development of effective therapeutic interventions. This new two-volume set, Cellular and Molecular Mechanism in Alzheimer’s Disease Therapeutics, presents a detailed exploration of the cellular and molecular processes that drive the onset and progression of Alzheimers disease. The volume brings together leading experts who offer insights into the intricate cellular and molecular pathways involved in AD pathology as well as potential therapeutic targets and innovative treatment strategies.

Volume 1: Cellular Mechanism in Alzheimer’s Disease Therapeutics presents a detailed and up-to-date exploration of the cellular processes involved in AD, with an emphasis on their implications for therapeutic interventions. The book offers a comprehensive understanding of how various cellular mechanisms, such as synaptic dysfunction, neuroinflammation, mitochondrial impairment, and protein aggregation, contribute to the pathology of disease. Topics include blood-brain barrier dysfunction in AD, personalized medicine approaches based on genetic profiling, microRNAs in the management of disease, and more.

Volume 2: Molecular Mechanism in Alzheimer’s Disease Therapeutics provides a comprehensive understanding of the disease at a molecular level, from the misfolding and aggregation of amyloid-beta and tau proteins to the disruptions in cellular homeostasis, mitochondrial dysfunction, and neuroinflammation. The volume presents some emerging tools and novel therapeutics and also discusses pharmacological modulation of neurodegenerative disorders, behavioral intervention and cognitive training in AD management, customizing therapies to individual genetic and molecular characteristics, ethical considerations in clinical trials and research, international efforts in AD research and treatment, and more. This volume bridges the gap between molecular research and therapeutic applications, shedding light on the latest findings related to disease mechanisms, such as oxidative stress, synaptic alterations, and the role of neuroinflammatory pathways.

Unlike other texts, these two volumes integrate the latest research on biomarkers, drug development, and innovative treatment strategies, offering a comprehensive and up-to-date resource. The unique focus on both fundamental science and practical therapeutic applications makes this two-volume set an invaluable guide for researchers, clinicians, and students aiming to advance their understanding and treatment of disease. By focusing on the cellular and molecular insights into this disease, these volumes pave the way for inspiring novel therapeutic approaches that address the root causes of neurodegeneration.

Click here for Cellular and Molecular Mechanisms in Alzheimer's Disease Therapeutics, 2-volume set: Volume 1: Cellular Mechanisms
Volume 2: Molecular Mechanisms


Click here for Cellular and Molecular Mechanisms in Alzheimer's Disease Therapeutics, Volume 1: Cellular Mechanisms


Click here for Cellular and Molecular Mechanisms in Alzheimer's Disease Therapeutics, Volume 2: Molecular Mechanisms

CONTENTS:
Preface

1. Exploring the Cellular and Molecular Mechanisms, Pathogenesis, Etiology, and Complications of Alzheimer’s Disease

Sandeep Hurpade, Sharad Tayade, Prashant Nikumbh, Devendra Singh Lodhi, Pradeep Golani, and Sanjay Nagdev

2. Epigenetic Alterations in Alzheimer’s Disease: DNA Methylation and Histone Modifications with Non-Coding DNA Involvement
Komal Bhati, Rahul Kaushik, Praveen Kumar Gaur, Kanak Lata, and Puja Sinoriya

3. Neuroinflammation and Role of Peripheral Immune Cells in Alzheimer’s Disease
Shweta Shrivastava, Santosh Kumar Singh, and Manish Kumar Jeengar

4. Blood-Brain Barrier Dysfunction: Relevance to Alzheimer’s Disease Pathology and Challenges and Opportunities in Drug Discovery
Sandeep Prasad Tiwari and Dipti Pal

5. Interdisciplinary Methods: The Integration of Neurology, Genetics, and Systems Biology Approaches to Comprehend Alzheimer’s Disease
Phool Chandra, Himanshu Sharma, and Neetu Sachan

6. Personalized Medicine Approaches Based on Genetic Profiling in the Treatment of Alzheimer’s Disease
Sakshi Soni, Parveen Rawat, Vandana Soni, and Sushil K. Kashaw

7. Integration of Biomarker Data into Clinical Trials and Personalized Treatment Plans
Ahana Hazra, Rideb Chakraborty, Naureen Afrose, Pratibha Bhowmick, Chowdhury Mobaswar Hossain, and Mithun Bhowmick

8. Role of Oxidative Stress and Mitochondrial Dysfunction in Progression of Alzheimer’s Disease and Its Emerging Phyto-Therapeutic and Nanomedicinal Interventions
Snigdha Bhardwaj, Radha Goel, Rosaline Mishra, and Mohd Yasir

9. MicroRNAs in the Management of Alzheimer’s Disease: Significant Approaches as Diagnostic Biomarkers
Avijit Bej, Nandita Mandal, Anwesha Das, and Arijit Nandi

10. Cellular Symphony: Harmonizing Therapeutic Approaches for Alzheimer’s Disease Through Targeted Intervention Strategies
Shubhrat Maheshwari, Anas Islam, Purba Mandal, Aditya Singh, Asad Ahmad, Mohammad Irfan, Badruddeen, Mohammad Ahmad, and Juber Akhtar

11. Exploring the Role of the Gene Mutation in the Management of Alzheimer’s Disease
Varsha Yadav, Sinchan Das, and Arjun Patra

Index


About the Authors / Editors:
Editors: Prashant Tiwari, PhD
Associate Professor, Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India

Prashant Tiwari, PhD, is an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He has over a decade of experience in the field of teaching and research related to pharmacology. His expertise includes drug screening, method validation for brain-targeted drug delivery, drug-induced dyskinesia revalidation, and the neuroprotective effects of benzimidazole derivatives. His research has explored the dopaminergic pathway, prolactin inhibition, and neuroprotection, with notable studies on nanoemulsions containing Lepidium sativum oil for Parkinson’s disease and Muntingia calabura leaf extract for Alzheimer’s disease. For his outstanding work, Dr. Tiwari received the Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences (2022). In addition to his research, Dr. Tiwari has authored five books, edited five books, and co-authored six book chapters. He has filed seven patents, two of which have been granted. He organized a national e-seminar on targeted drug delivery against neurodegenerative diseases, sponsored by the Department of Biotechnology (DBT), Government of India. Dr. Tiwari has been honored with various awards as well. He supervises five PhD students and has guided nine MPharm students. He is also an active member of professional bodies and serves as a peer reviewer for international journals. His research interests span neurodegenerative disorders, drug interactions, pharmacokinetics/pharmacodynamics, and metabolic disorders. He holds a PhD from Siksha O Anusandhan University, Bhubaneswar, and was a fellow of the Indian Council of Medical Research (ICMR), New Delhi, India.

Sunil Kumar Kadiri, PhD
Professor, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India

Sunil Kumar Kadiri, PhD, is currently working as a Professor in the College of Pharmaceutical Sciences at Dayananda Sagar University, Bengaluru, Karnataka, India. He has 16 years of experience in teaching. His area of interest is neuropharmacology and drug interactions. He has over 50 research and review publications to his credit as well as four books and three patents. He is a professional member of the Association of Pharmaceutical Teachers of India. Dr. Kadiri completed his PhD in Pharmaceutical Sciences at JNTU Hyderabad, Telangana, India.

Kunjbihari Sulakhiya, PhD
Assistant Professor, Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

Kunjbihari Sulakhiya, PhD, is working as an Assistant Professor at the Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India. He has published over 20 research papers, seven review articles, and more than 10 book chapters. He has received 13 awards and fellowships, including six travel awards to present his research papers at international conferences in the USA, Canada, Japan, France, and Macau. He is a member of various professional societies, including the Indian Academy of Neurosciences, the International Society for Neurochemistry, Asia Pacific Society for Neurochemistry, Association of Pharmaceutical Teachers of India, etc. He is serving as an editorial member and reviewer for various reputed journals. His area of research is pre-clinical research in the field of neuropharmacology. He earned his MPharm and PhD in Pharmacology and Toxicology at the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India.




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