Nanomedicine

Biomarkers as Targeted Herbal Drug Discovery
A Pharmacological Approach to Nanomedicines

Editors: Mahfoozur Rahman, PhD
Sarwar Beg, PhD
Mazin A. Zamzami, PhD
Hani Choudhry, PhD
Aftab Ahmad, PhD
Khalid S. Alharbi, PhD

Biomarkers as Targeted Herbal Drug Discovery

Published. Available now.
Pub Date: July 2021
Hardback Price: see ordering info
Hard ISBN: 9781771889025
E-Book ISBN: 9781003045526
Pages: 362 pp w/ index
Binding Type: Hardback
Notes: 14 color and 16 b/w illustrations


Reviews
“A very interesting compilation of the translational components of the science and technology that, in particular, focuses on their herbal drug delivery and targeting on various biomarkers, which are involved in the treatment of various dreadful disorders, including arthritis, cardiovascular, ocular disorders, cancers, etc. . . . An important tool for herbal drug discovery based on biomarkers. . . . [Also] discusses herbal constituents to target the biomarkers involved in various threatening diseases, including parasitic disease, immune-related disorders, cancers, etc., and its management by using bioactive loaded nanomedicines . . . A wonderful treatise based on expert experience with a clear bearing on application in human health.”
—From the Foreword by Most Rev. Prof. Rajendra B. Lal, Vice Chancellor, Sam Higginbottom University of Agriculture, Technology and Science, India

This new volume looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits.

Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid.

Biomarkers as Targeted Herbal Drug Discovery: A Pharmacological Approach to Nanomedicines discusses phytoconstituent-based nanotherapeutics with applications for some specific health issues, such as arthritis, leishmanicidal, cardiovascular diseases, cancer, ocular disorders, etc.

With chapters contributed by eminent scientists, researchers, and nanotechnologists from across the globe, this volume highlights the key advancements, challenges, and opportunities in the application of herbal drug discovery based on biomarkers and its delivery by nanomedicines for disease treatment and regulatory guidelines.

Key features

  • Reviews the literature on inflammatory biomarkers in the treatment of diseases
  • Looks at the development of herbal drug discovery based on biomarkers
  • Explores emerging concepts of nanomedicines for herbal drug delivery
  • Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
This volume will be very useful for pharmaceutical scientists, nanoscientists, nanobiotechnologists, and others associated with this realm and who are engaged in the discipline of healthcare systems.

CONTENTS:
Preface

1. Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, and Sarwar Beg

2. Herbal Anti-Arthritic Drug Discovery Tool Based on Inflammatory Biomarkers
Mahfoozur Rahman, Ankit Sahoo, andSarwar Beg

3. Curcumin Nanomedicines and Their Application in the Management of Disease
Sadaf Jamal Gilani, Syed Sarim Imam, Md. Jafer, Sultan Alshehri, Md. Taleuzzaman, and Mohd. Asadullah Jahangeer

4. Ursolic Acid: A Pentacyclic Triterpene from Plants in Nanomedicine
Monalisha Sen Gupta, Md. Adil Shaharyar, Mahfoozur Rahman, Kumar Anand, Imran Kazmi, Muhammad Afzal, and Sanmoy Karmakar

5. Phytoconstituent-Centered Byproducts and Nanomedicines as Leishmanicidal Scavengers
Sabya Sachi Das, P. R. P. Verma, and Sandeep Kumar Singh

6. Delivery of Herbal Cardiovascular Drugs in the Scenario of Nanotechnology: An Insight
Kumar Anand, Subhabrata Ray, Md. Adil Shaharyar, Mahfoozur Rahman, Rudranil Bhowmik, and Sanmoy Karmakar

7. Nigella sativa Encapsulated Nano-Scaffold and Their Bioactivity Significance
Mohammed Asadullah Jahangir, Abdul Muheem, Syed Sarim Imam, Farhan Jalees Ahmed, and Mohd. Aqil

8. Phytoconstituent-Loaded Nanomedicines for Arthritis Management
Syed Salman Ali, Chandra Kala, Najam Ali Khan, Mohd. Abid, Alankar Shrivastva, Syed Sarim Imam, and Snigdha Bhardwaj

9. Phytoconstituent-Based Nanotherapeutics as Ocular Delivery Systems
Mohammed Jafar, Syed Sarim Imam, and Syed Azizullah Ghori

10. Rosmarinic Acid: A Boon in the Management of Cardiovascular Disease
Md. Adil Shaharyar, Mahfoozur Rahman, Kumar Anand, Chowdhury Mobaswar Hossain, Imran Kazmi, and Sanmoy Karmakar

11. Long-Term Toxicity and Regulations for Bioactive-Loaded Nanomedicines
Iqbal Ahmad, Sobiya Zafar, Shakeeb Ahmad, Suma Saad, S.M. Kawish, Sanjay Agarwal, and Farhan Jalees Ahmad

12. Resveratrol-Loaded Phytomedicines for Management of Cancer
Shakir Saleem, Ruqaiyah Khan, and Sandeep Arora

13. Thymoquinone-Loaded Nanocarriers for Healthcare Applications
Ruqaiyah Khan, Himani Nautiyal, and Shakir Saleem


Index


About the Authors / Editors:
Editors: Mahfoozur Rahman, PhD
Assistant Professor, Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, India

Mahfoozur Rahman, PhD, is an Assistant Professor in the Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Allahabad, India. His major areas of research interest include development and characterization of nanosized drug delivery systems for inflammatory disorders, including psoriasis, arthritis, neurodegenerative disorders, cancer, etc. In addition, he is also working on amalgamation of herbal medicinal plants with modern therapeutics in order to deliver scientifically acceptable therapies for various diseases management. To date he has published over 100 publications in peer-reviewed journals, such as Seminar in Cancer Biology, Drug Discovery Today, Nanomedicine, etc. He has also published 20 book chapters, five international books, and three articles in international journals. Overall, he has earned highly impressive publishing and citation record in Google Scholar (H-index of 23, total citations: over 1,400 to date). Dr. Rahman has received travel grants from various international congresses, such as IAPRD, MDS, Nano Today Conference, KSN 2019, etc. He is also serving as an editorial board member and guest editor for several journals.

Sarwar Beg, PhD
Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Sarwar Beg, PhD, is an Assistant Professor in the Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has over a decade of teaching and research experience in the field of pharmaceutics and biopharmaceutics, especially in the development of novel and nanostructured drug delivery systems using Quality-by-Design paradigms. Before joining Jamia Hamdard, Dr. Beg worked as a Research Scientist at Jubilant Generics Limited, Noida, India. He has authored over 150 publications, 48 book chapters, 10 books, three Indian patent applications and served as a guest editors of several international journals. He has a Google Scholar H-Index of 26 and over 2800 citations to his credit.

Mazin A. Zamzami, PhD
Associate Professor in Clinical Biochemistry, Chairman of the Biochemistry Department, Faculty of Science at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

Mazin Zamzami, PhD, is an Associate Professor in Clinical Biochemistry and the Chairman of the Biochemistry Department, Faculty of Science at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. Dr. Zamzami joined the KAU family in 2002 as a Lecturer in Biochemistry in the Faculty of Health Sciences. Previously, Dr. Zamzami directed the Serology Department as well as worked as a senior laboratory technician in the Clinical Biochemistry Department at Al-Thagher Hospital, Jeddah, Saudi Arabia, for approximately five years. His clinical research interest is in the molecular basis of disease, particularly nucleotide metabolic diseases, and pharmacogenetics. He has several published articles and has presented papers at international and national scientific conferences.

Hani Choudhry, PhD
Assistant Professor of Cancer Genomics and the Head of Cancer and Mutagenesis Unit at the King Fahd Center for Medical Research in King Abdulaziz University (KAU), Saudi Arabia

Hani Choudhry, PhD, is an Assistant Professor of Cancer Genomics and the Head of Cancer and Mutagenesis Unit at the King Fahd Center for Medical Research at King Abdulaziz University (KAU), Saudi Arabia. He is also a Visiting Assistant Professor at the NIH Center of Excellence in Genomic Science, Center for Personal Dynamic Regulome, School of Medicine, Stanford University, California, USA. Dr. Choudhry has received a number of international and prestigious awards, including two AACR Scholar-in-Training Awards, the Susan G. Komen for the Cure Award and Proffered Paper Award for Non-coding RNA in Cancers at the EACR Annual Meeting. He has published over 40 research articles in high-impact and respected scientific journals.

Aftab Ahmad, PhD
Associate Professor of Pharmacology, Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

Aftab Ahmad, PhD, is an Associate Professor of Pharmacology in the Health Information Technology Department at Jeddah Community College of King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. He had completed numerous research projects as a principle investigator (PI) funded by the deanship of scientific research (DSR) of King Abdulaziz University. He has contributed more than 100 full-length research articles to reputable national and international journals and is also an expert reviewer for several journals. His current h-index is 13, and he has been cited over 1,400 times to date.

Khalid S. Alharbi, PhD
Assistant Professor of Pharmacology and Toxicology; Head of the Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia

Khalid S. Alharbi, PhD, is an Assistant Professor of Pharmacology and Toxicology and the Head of the Pharmacology Department, College of Pharmacy at Jouf University, Sakaka, Saudi Arabia. He obtained both his BSc (Pharmaceutical Sciences, 2002) and MSc (Toxicology, 2009) from the College of Pharmacy at King Saud University (KSU), Riyadh, Saudi Arabia. He was awarded his PhD (Pharmacy and Biomedical Sciences, 2016) from Stathclyde University, United Kingdom. Dr. Alharbi’s major area of research is cancer including drug discovery, nanomedicine, and preclinical pharmacological and toxicological studies of anticancer agents. He has published several articles in peer-reviewed journals and has presented papers at numerous international conferences.




Follow us for the latest from Apple Academic Press:
Copyright © 2024 Apple Academic Press Inc. All Rights Reserved.