Biotechnology

Rediscovering Cancer
From Mechanism to Therapy

Sayali Mukherjee, PhD
Somali Sanyal, PhD
Sonia Chadha, PhD

Rediscovering Cancer

In production
Pub Date: February, 2018
Hardback Price: $199.95 US
Hard ISBN: 9781771886901
Pages: Approx 625p w/Index
Binding Type: hardback
Notes: 40 b/w illustrations

This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.

Rediscovering Cancer: From Mechanism to Therapy also includes some recent research on the therapeutic aspects of cancer. Chapters related to immunotherapy, chemotherapy, and use of chitosan-based nanoparticles for cancer therapy are included, with emphasis on preventive measures for cancer.

Overall, this informative volume covers the present knowledge and future direction on the field of cancer research.

CONTENTS:
Preface

PART I: MOLECULAR MECHANISMS UNDERLYING INITIATION, PROMOTION, AND PROGRESSION OF CANCER
1. Genetic Instability in Cancer
Gloria Ravegnini, Patrizia Hrelia, and Sabrina Angelini

2. Oncogenesis and Telomerase Activity in Cancer
Sutapa Mukherjee, Madhumita Roy, and Jaydip Biswas

3. Cell Cycle Checkpoints in Cancer
Sreeparna Chakraborty and Abhik Sen

4. Angiogenesis, Its Importance and Implication in Tumor Growth and Progression and in Anticancer Therapy: An Update
Chandrani Sarkar and Debanjan Chakroborty

5. The Tumor Microenvironment and Metastasis
Sonia Chadha

6. Apoptosis: A Regulatory Mechanism in Cancer
Sutapa Mukherjee, Apurba Mukherjee, Souvick Biswas, and Madhumita Roy

7. Cytoplasmic Signaling Circuitry: An Important Trait of Cancer
Subhra Dash, K. Lohitesh, and Sudeshna Mukherjee

PART II: CANCER ETIOLOGY: PHYSICAL, CHEMICAL, ENVIRONMENTAL FACTORS, AND GENETIC SUSCEPTIBILITY
8. Cancer: An Overview of Risk Factors
Sayali Mukherjee and Shabana Siddique

9. Single Nucleotide Polymorphisms as Susceptibility Markers for Cancer
Suresh Kumar Yadav and Somali Sanyal

PART III: CANCER PREVENTION AND CONVENTIONAL THERAPIES
10. Dietary Phytochemicals in the Prevention and Therapy of Cancer: Modulation of Molecular Targets
Shamee Bhattacharjee

11. Health Benefits and Preventive Effects of Common Beverages in Cancer
Vivek Kumar Gaur, Sanjay Gupta, and Janmejai Kumar Srivastava

12. Cancer Chemotherapy
Sonal Srivastava, Sakshi Mishra, Jayant Dewangan, Aman Divakar, Prabhash Kumar Pandey, and Srikanta Kumar Rath

PART IV: NOVEL THERAPEUTIC APPROACHES FOR CANCER
13. Non-Coding RNAs : The New Reins in Malignancies
Deba Prasad Mandal

14. Epigenetics in Cancer Prevention and Therapy: Role of Phytochemicals
Sajid Khan, Samriddhi Shukla, and Syed Musthapa Meeran

15. Cancer Stem Cell: Current Understanding and Future Perspectives
Sonal Srivastava, Jayant Dewangan, Divya Tandon, and Srikanta Kumar Rath

16. Tumor Microenvironment and Cancer Stem Cells: Therapeutic Potential of Epigenetic Inhibitors to Target CSCs
Anup Kumar Singh, Priyank Chaturvedi, and Dipak Datta

17. Nanoparticles in Cancer Therapy
Madhuchanda Banerjee

18. Cancer Immunotherapy: Extending New Horizons in Cancer Treatment
Deba Prasad Mandal

Index


About the Authors / Editors:
Sayali Mukherjee, PhD
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India

Sayali Mukherjee, PhD, is an Assistant Professor at the Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She completed her PhD from the Chittaranjan National Cancer Institute, Kolkata India, registered under Jadavpur University in Life Sciences. She received a NET-CSIR Research Fellowship. During her PhD she has worked on the toxicological and carcinogenic effects of air pollutants on human health. After completing her PhD, she has worked on stem cell culture as a Research Associate at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. Presently she is working on immunological and biochemical aspects of oral cancer and oral diseases. She has several publications in peer-reviewed journals of national and international repute.

Somali Sanyal, PhD
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India

Somali Sanyal, PhD, is an Assistant Professor at Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She received her PhD from the Karolinska Medical University, Stockholm, Sweden. During her PhD she has worked on molecular epidemiology of urinary bladder cancer. After her PhD she worked as a postdoctoral fellow at the Karolinska Medical University, Stockholm, Sweden. Later on she moved to the Central Drug Research Institute, Lucknow, India, as a Research Associate. Her current research focuses on genetic aspects of head and neck, oral, and gall bladder cancer. She has published several research articles in journals of national and international repute.

Sonia Chadha, PhD
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India

Sonia Chadha, PhD, is presently working as a faculty member at the Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She completed her PhD from the Central Drug Research Institute, Lucknow, India, in biochemistry. During her PhD she has worked on the interaction of rat polymorphonuclear leukocyte derived free radical generation and nitric oxide in normal and in various pathological conditions. She has pursued her PDF from the National Environmental Engineering Research Institute (NEERI), Nagpur, India, where she worked on cytochrome P450. Her research interests include biochemical and molecular aspects of cancer and hypertensive disorders. She has several publications in national and international peer-reviewed journals.




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