Bioinformatics

Omics in Clinical Practice
Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research

Editor: Yu Liu, PhD

Omics in Clinical Practice

Published. Available now.
Pub Date: June 30, 2014
Hardback Price: $169.95 US
Hard ISBN: 9781771880602
E-Book ISBN: 9781482262438
Pages: 464pp
Binding Type: hardbound

This title includes a number of Open Access chapters.



The term “omics” describes a wide range of biological fields, all of which seek to describe how the characterization of molecules translates into the structure and function of an organism. This volume serves as introduction to four of these fields—genomics, pharmacogenomics, proteomics, and transcriptomics—looking specifically, in this case, at the study of omics in relation to human disease. Included in the text are a wide range of chapters that relate omics to:
  • the role of translational and personalized medicine
  • molecular and genetic markers
  • pathogen detection, evolution, and infection
  • companion diagnostics
  • clinical applications and research
This easily accessible reference volume offers a comprehensive guide to one facet in a much larger field of research. Edited by a researcher from the Center for Proteomics and Bioinformatics at Case Western Reserve University, Omics in Clinical Practice: Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research is an authoritative and easy-to-use reference, ideal for both researchers in the field and those who wish to gain a better perspective on the field of omics by examining it through the lens of human disease.

The book:
  • introduces genomics, proteomics, and trascriptomics in realtion to human disease and ailments
  • considers the role of translation and personalized medicine in relation to genomics, proteomics, and trascriptomics
  • covers molecular and genetic markers
  • considers the role of genomics, proteomics, and trascriptomics in relation to pathogen detection, evolution and infection
  • covers companion diagnostics in relation to genomics, proteomics, and trascriptomic clinical applications and research

CONTENTS:
Introduction
Part 1: Omics and Human Disease
Chapter 1. Comparative Mitochondrial Proteomics: Perspective in Human Diseases
Yujie Jiang and Xin Wang

Chapter 2. Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches
Elena Silvestri, Assunta Lombardi, Pieter de Lange, Daniela Glinni, Rosalba Senese, Federica Cioffi, Antonia Lanni, Fernando Goglia, and Maria Moreno

Chapter 3. Next Generation Sequencing in Cancer Research and Clinical Application
Derek Shyr and Qi Liu

Chapter 4. Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice
Y. W. Francis Lam

Part 2: Translational and Personalized Medicine
Chapter 5. Clinical Proteomics and Omics Clues Useful in Translational Medicine Research
Elena López, Luis Madero, Juan López-Pascual, and Martin Latterich

Chapter 6. Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data
David Toomey, Heinrich C. Hoppe, Marian P. Brennan, Kevin B. Nolan, and Anthony J. Chubb

Part 3: Molecular and Genetic Markers
Chapter 7. Pitfalls and Limitations in Translation from Biomarker Discovery to Clinical Utility in Predictive and Personalised Medicine
Elisabeth Drucker and Kurt Krapfenbauer

Chapter 8. How Bioinformatics Influences Health Informatics: Usage of Biomolecular Sequences, Expression Profiles and Automated Microscopic Image Analyses for Clinical Needs and Public Health
Vladimir Kuznetsov, Hwee Kuan Lee, Sebastian Maurer-Stroh, Maria Judit Molnár, Sandor Pongor, Birgit Eisenhaber, and Frank Eisenhaber

Chapter 9. Application of “Omics” to Prion Biomarker Discovery
Rhiannon L. C. H. Huzarewich, Christine G. Siemens, and Stephanie A. Booth

Part 4: Omics and Pathogens
Chapter 10. Insights from Genomics into Bacterial Pathogen Populations
Daniel J. Wilson

Chapter 11. High Throughput Sequencing and Proteomics to Identify Immunogenic Proteins of a New Pathogen: The Dirty Genome Approach
Gilbert Greub, Carole Kebbi-Beghdadi, Claire Bertelli, François Collyn, Beat M. Riederer, Camille Yersin, Antony Croxatto, and Didier Raoult

Chapter 12. Coronavirus Genomics and Bioinformatics Analysis
Patrick C. Y. Woo, Yi Huang, Susanna K. P. Lau, and Kwok-Yung Yuen

Part 5: Companion Diagnostics
Chapter 13. Applications of Next-Generation Sequencing Technologies to Diagnostic Virology
Luisa Barzon, Enrico Lavezzo, Valentina Militello, Stefano Toppo, and Giorgio Palù

Chapter 14. Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture
Debasish Paul, Avinash Kumar, Akshada Gajbhiye, Manas K. Santra, and Rapole Srikanth

Index


About the Authors / Editors:
Editor: Yu Liu, PhD
Senior Research Associate, Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio

As a bioinformatician, Dr. Yu Liu’s research is centered on the development and application of computational tools for the study of complex diseases. He has extensive experience with data generated from microarrays, next generation sequencing and high-resolution mass spectrometry, and developing bioinformatics tools and applying system biology approach to study complex diseases, like sleep apnea, neurodegenerative diseases, and cancers. More recently, he developed a systems biology approach that enables the discovery of high-level disease mechanisms and provides testing hypotheses for further research. Currently, Dr. Liu is a senior research associate at the Center for Proteomics and Bioinformatics at Case Western Reserve University, Cleveland, Ohio. He received a PhD in Bioinformatics from Montreal University, Montreal, Canada, and has postdoc training from the University of Toronto, Canada.




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