Nutrition, Dietetics & Health

Health and the Gut
The Emerging Role of Intestinal Microbiota in Disease and Therapeutics

Editor: William Olds

Health and the Gut

2014. Available now.
Pub Date: August 2014
Hardback Price: $169.95 US
Hard ISBN: 9781771880725
E-Book ISBN: 978-1-4987-0126-6
Pages: 378 pages with index
Binding Type: hardbound

This title includes a number of Open Access chapters.

The study of the intestinal ecosystem of bacteria in the human gut—the gut microbiome—is a new field that is rapidly evolving. This book serves as an introduction to some of the new and exciting research that is being done in this field. Included are chapters that examine the following:
  • gut microbiome’s roles in the pathogenesis of obesity and autoimmune disease
  • the effect of nutrition on the richness of the microbial community
  • the stability of the microbiome to various stressors
  • emerging ways to diagnose diseases using the microbiome
  • exciting prospects for using these microbes to cure disease
This easily accessible reference volume offers a comprehensive guide to this relatively new field of study. Edited by a researcher from Yale University, Health and the Gut: The Emerging Role of Intestinal Microbiota in Disease and Therapeutics is an authoritative and easy-to-use reference, ideal for both researchers in the field and those who wish to gain more information about the impact of gut microbiota on human health.


Part I: Introduction: The Rainforest in the Gut
1. Nutrition, Microbiomes, and Intestinal Inflammation
Suzanne Devkota and Eugene B. Chang

Part II: Microbiome's Role in Obesity
2. Gut Microbiota: In Sickness and in Health
M. José Huertas and Carmen Michán
3. Microbial Reprogramming Inhibits Western Diet-Associated Obesity
Theofilos Poutahidis, Markus Kleinewietfeld, Christopher Smillie, Tatiana Levkovich, Alison Perrotta, Siddheshvar Bhela, Bernard J. Varian,Yassin M. Ibrahim, Jessica R. Lakritz, Sean M. Kearney, Antonis Chatzigiagkos, David A. Hafler, Eric J. Alm, and Susan E. Erdman
4. Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice
Yan Y. Lam, Connie W. Y. Ha, Craig R. Campbell, Andrew J. Mitchell, Anuwat Dinudom, Jan Oscarsson, David I. Cook, Nicholas H. Hunt, Ian D. Caterson, Andrew J. Holmes, and Len H. Storlien
5. Bacteroides uniformis CECT 7771 Ameliorates Metabolic and Immunological Dysfunction in Mice with High-Fat-Diet Induced Obesity
Paola Gauffin Cano, Arlette Santacruz, Ángela Moya, and Yolanda Sanz
6. Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in Diet-Induced Obese Mice Is Associated with Gut Microbial Changes and Reduction in Obesity
Do-Young Park, Young-Tae Ahn, Se-Hoon Park, Chul-Sung Huh, Sae-Rom Yoo, Rina Yu, Mi-Kyung Sung, Robin A. McGregor, and Myung-Sook Choi

Part III: Inflammation and Innate Immunity
7. Antimicrobial Peptides and Gut Microbiota in Homeostasis and Pathology
Maureen J. Ostaff, Eduard Friedrich Stange, and Jan Wehkamp
8. Matrix Metalloproteinase 13 Modulates Intestinal Epithelial Barrier Integrity in Inflammatory Diseases by Activating TNF
Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, SofieLodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin, and Claude Libert

Part IV: Nutrition's Effect on the Microbiome
9. Impact of a Synbiotic Food on the Gut Microbial Ecology and Metabolic Profiles
Beatrice Vitali, Maurice Ndagijimana, Federica Cruciani, Paola Carnevali, Marco Candela, Maria Elisabetta Guerzoni, and Patrizia Brigidi
10. Diet-Microbiota Interactions and their Implications for Healthy Living
Ian B. Jeffery and Paul W. O’Toole

Part V: Using the Microbiome to Identify and Cure Disease
11. Prebiotics, Faecal Transplants and Microbial Network Units to Stimulate Biodiversity of the Human Gut Microbiome
Pieter Van den Abbeele, Willy Verstraete, Sahar El Aidy, Annelies Geirnaert, and Tom Van de Wiele
12. Microbiota and Healthy Aging: Observational and Nutritional Intervention Studies
Harald Brüssow
13. Gut Pharmacomicrobiomics: The Tip of an Iceberg of Complex Interactions between Drugs and Gut-Associated Microbes
Rama Saad, Mariam R. Rizkallah, and Ramy K. Aziz
14. Fame and Future of Fecal Transplantations: Developing Next-Generation Therapies with Synthetic Microbiomes
Willem M. de Vos

About the Authors / Editors:
Editor: William Olds
Molecular Cell Biology, Genetics and Development, Yale University, New Haven, Connecticut, USA

William Olds is a graduate student at Yale University in the laboratory of Tian Xu. His work focuses on satiety signals from the gut and how that communication to the brain breaks down in the pathogenesis of obesity.

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