The Sweet Enigma

Tanveer A. Dar, PhD
Adeel Malik, PhD

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The volume, Glycome: The Sweet Enigma, provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research. The volume thoroughly deals with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process and in disease etiology. It bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of glycome in various diseases as a therapeutic marker has also been highlighted.

Although being so vital component of life, studies of glycans lagged far behind than those of other major classes of molecules. This lag in glycan biology has been argued to be due to their inherent structural complexity, the difficulty in easy sequence determination, and the inability to predict their biosynthesis from a genetic template. In an attempt to elucidate this enigma, scientists have developed a variety of new technologies for exploring the complexity of these sugar chains, which have really opened up the new frontier of molecular biology, called as glycobiology. However, understanding this enigma of identifying/characterizing the glycome and its interactions with carbohydrate binding proteins still remains a major challenge.

This book attempts addresses that challenge. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture as far as glycome is concerned. The volume also addresses the latest developments and future challenges of glycome biology.

Tentative Contents
Glycome as a Glycan Cell Signature
1. Structural and Functional Roles of Glycans in Biological Processes
2. Glycome in the Maintenance of Folding, Stability, and Immunogenic Properties of Biological Molecules
3. Glycome in the Maintenance of Homeostasis
4. Decoding the Glycome
5. Defects in Human Glycome
6. Glycome in Immunological Processes
7. Glycome as Mediator of Metastasis
8. Application of Glycomicprofiling in Diagnostics
9. Glycome in Therapeutic Applications: Glycotherapy
10. Glycome as Clinical Biomarkers of Ageing: Basics and Advances
11. Effect of Epigenetic Modulation on Human Glycome
12. Glycome in Host-Pathogen Interactions
13. Glycome Profiling in Plants
14. Recent Technological Advances in Glycome Analysis
15. Challenges in Glycome Research
Glossary of Terms

About the Authors / Editors:
Tanveer A. Dar, PhD
Assistant Professor of Clinical Biochemistry, University of Kashmir Srinagar, Jammu & Kashmir, India
Tanveer A. Dar, PhD, is currently Assistant Professor of Clinical Biochemistry at the University of Kashmir Srinagar, Jammu & Kashmir, India. He has published more than 25 research papers in high-impact international journals. Dr. Dar has been actively involved in teaching and research from last eight years and has been awarded with a Junior Research Fellowship and a Senior Research Fellowship by the Council of Scientific and Industrial research (CSIR), New Delhi, India. He was selected as an Indian National Science Academy (INSA) Visiting Fellow for the year 2014-2015. Dr. Dar is actively involved in various projects with funding from various reputed national funding agencies, such as the Department of Biotechnology, the Department of Science and Technology and CSIR, Govt. of India, New Delhi. His current research focuses on modulation of protein fibrillation/aggregation by chemical chaperones, such as trehalose, mannose, TMAO, sucrose, sorbitol, etc., and characterization of therapeutically important glycoproteins from medicinal plants. He has recently published an edited volume book, Proteiostasis and Chaperone Surveillance, published by Springer, India Ltd. Dr. Dar received his Master’s in biochemistry from Hamdard University, New Delhi, India, and his PhD in protein biophysics from Jamia Millia Islamia, New Delhi. Dr. Dar continued his postdoctoral research at the University of Montana, USA.

Adeel Malik, PhD
Assistant Professor, Perdana University Centre for Bioinformatics (PU-CBi), Selangor, Malaysia
Adeel Malik, PhD, is an Assistant Professor at the Perdana University Center for Bioinformatics (PU-CBi), Malaysia. He obtained his PhD (2009) from the Dept. of Biosciences, Jamia Millia Islamia (JMI), New Delhi, India. During his PhD, he developed computational methods for the prediction of carbohydrate binding sites in proteins using sequence and evolutionary information (Malik and Ahmad, BMC Struct Biol, 2007). This was the first sequence-based method to predict carbohydrate-binding sites in proteins, which was well received by the scientific community. Realizing that it is not easy to retrieve protein-carbohydrate complexes from PDB, he continued this work as a scientist at the Biomedical Informatics Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, where he developed an elaborate database of protein-carbohydrate complexes, integrating sequence-based prediction tools in it ( He obtained his postdoctoral fellowship from the School of Computational Sciences, Korea Institute for Advanced Study (KIAS), Seoul, South Korea. As a part of his research, he explored lectin-carbohydrate interactions via community-based network analysis by using glycan array data. Later he worked as an Assistant Professor at School of Biotechnology, Yeungnam University, South Korea. His other research interests include the study of chronic kidney diseases, skeletal muscle development, and understanding the role of glycogenes in various biological processes by using different bioinformatics methods. He has published about 19 research articles in high-impact journals including 3 book chapters.

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