Biomedical Engineering/Nanotechnology

Dendrimers in Medical Science
Zahoor Ahmad Parry, PhD
Rajesh Pandey, MD

Dendrimers in Medical Science

Published. Available now.
Pub Date: June 2017
Hardback Price: $149.95 US
Hard ISBN: 9781771884419
E-Book ISBN: 978-1-315-36600-5
Pages: 382pp with index
Binding Type: hardback
Notes: 6 color and 15 B/W illustrations

“Among various recent books on dendrimers, this one focuses on the very promising, but still challenging, field of nanomedicine/personalized medicine. It is not exhaustive, as the field is already very broad, but, besides classical topics such as drug and gene delivery and diagnosis, it deals also with topics rarely discussed previously, such as molecular modeling, toxicity studies, and it addresses also emerging areas. An inspiring book for the dendrimers community, in chemistry, biology, and nanomedicine!”
Anne-Marie Caminade, CNRS, Laboratoire de Chimie de Coordination, Toulouse, France; and University of Toulouse, France

This valuable new book offers a new perspective on dendrimers that bridges the gap between basic research and applied nanomedicine. It explores the ultimate effectiveness of dendrimers in theranostics, a promising field that combines therapeutics and diagnostics into single multifunctional formulations used to affect therapy or treatment of a disease state. The authors examine the potential uses of dendrimers, which have proven their capabilities in local/systemic drug delivery, physical stabilization of the drug, solubility enhancement of the poorly soluble drugs, and gene delivery.

The research of leaders in the field of dendrimer research from around the globe has been compiled, with explanations and intepretations, to provide a comprehensive volume on the subject. The potential role of dendrimers in combating communicable as well as noncommunicable diseases is highlighted along with other pertinent examples of recent breakthroughs in dendrimer-based nanomedicine. At the same time, certain bottlenecks are also considered that may inhibit direct clinical adaptations of dendrimers at present, mainly because of their high cost of production, unpredictable behavior in living organisms, unknown bioavailability, biocompatibility or pharmacokinetics, issues with therapeutic dose selection, or toxicity.

In the last three decades, dendrimer research has gone from infancy into adolescence, and its entry into mature adulthood awaits toiling research input in the coming decades. This book provides an entryway to new research.

Key Features:

  • Examines potential issues of dendrimer design that need to be researched
  • Presents applications of dendrimers from the clinical viewpoint
  • Reviews toxicological aspects of dendrimers
  • Poses challenges concerning the ultimate effectiveness of dendrimers in theranostics
  • Draws from the available scientific literature with future projections
  • Describes relevant experimental techniques

Chapter 1. Introduction: Nanotechnology and Medical Science
Chapter 2. The Concept of Dendrimers
Chapter3. Synthesis and Types of Dendrimers
Chapter 4. Molecular Modeling Techniques to Study Dendrimers
Chapter 5. Dendrimer-Drug Interactions
Chapter 6. Dendrimers and Drug Delivery
Chapter7. Dendrimers and Gene Delivery
Chapter 8. Dendrimers in Diagnostics
Chapter 9. Miscellaneous Biomedical Applications of Dendrimers
Chapter 10. Toxicity of Dendrimers
Chapter 11. Emerging Aspects in Dendrimer Research

About the Authors / Editors:
Zahoor Ahmad Parry, PhD
Senior Scientist, Indian Institute of Integrative Medicine, Srinagar, India

Zahoor Ahmad Parry, PhD, is currently Senior Scientist at the Indian Institute of Integrative Medicine, Srinagar (Branch), in India. He has published over 25 research papers published in international journals and has written several book chapters. He has been the recipient of several research grants to study development of new drug regimens for the treatment of multi-drug resistant tuberculosis. In addition, he has participated at several international conferences and has given invited talks as well as served on several organizing committees. Dr. Parry has received several awards and honors for his research work. He is currently a member of the American Thoracic Society (ATS), the American Association of Microbiology (ASM), and the International Union against Tuberculosis and Lung Disease-NAR. His current research interests include nanotechnology-based drug delivery, drug development, and antimicrobial drug discovery.

Dr. Parry earned his PhD at PGIMER, Chandigarh, India, working on nanotechnology-based drug delivery. He also studied at the University of Kashmir and Johns Hopkins University (Baltimore, Maryland, USA).

Rajesh Pandey, MD
Professor and Head, Department of Biochemistry, MM Institute of Medical Sciences and Research, Mullana, Ambala (Haryana), India

Rajesh Pandey, MD, is currently Professor and Head, Department of Biochemistry, MM Institute of Medical Sciences and Research, Mullana, Ambala (Haryana), India. His clinical experience includes acting as House Physician for six months in the Department of Medicine, Medical College, Calcutta, India. Dr. Pandey has published two books, several book chapters, and over 100 articles in national and international journals. He has presented at a number of professional conferences and has participated in a number of workshops. He has organized webinars and meetings. He is an editorial board member of the European Journal of Pharmaceutical and Medical Research. Dr. Pandey earned his MD in biochemistry from the Medical College, Rohtak, India.

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